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These conclusions posture EBNA-3a just like a essential modulator of B cell proliferation and survival for the duration of EBV latency, and being a relevant CD8⁺ T cell objective in The 2 very simple immunological experiments and translational examine.
EBNA-3a appears to control a subset of mobile genes, many of which overlap with People controlled by EBNA2. The two proteins can act antagonistically or cooperatively to regulate gene expression. These results placement EBNA-3a for a vital modulator of B mobile proliferation and survival in the course of EBV latency, and as being a related CD8⁺ T mobile goal in the two standard immunological scientific studies and translational exploration.
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